Characterisation of dry powder inhaler formulations using atomic force microscopy
نویسندگان
چکیده
منابع مشابه
Dry powder inhaler formulation.
A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action. For the dry powder inhaler (DPI), these goals can be met with a suitable powder formulation, an efficient metering system, and ...
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Correspondence to Professor J Stuart Elborn; [email protected] Inhaled antibiotics are the backbone of care for people with cystic fibrosis (CF) who have lung infection due to Pseudomonas aeruginosa. They have significantly contributed to the improved quality of life (QOL) and increased survival in people with this disease. The systematic application of antibiotic eradication therapy for new o...
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Glucose monohydrate and sorbitol were evaluated as alternative carriers to á-lactose monohydrate in dry powder inhalations. Cromolyn sodium (CS) - carrier binary formulae were prepared and tested in vitro by aerosolization via a twin stage impinger using three types of inhaler devices; Spinhaler, Aerolizer and Handihaler. Glucose monohydrate and sorbitol-containing formulae that were inhaled vi...
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PURPOSE To study the influence of inspiratory flow rate on the fine particle mass and the particle size distribution for metered dose inhaler (MDI) and dry powder inhaler (DPI) glucocorticoid products, in vitro. To compare the performance of MDI and DPI inhalers containing the same drug and strength at an impaction flow rate of 60 L/min. METHODS The Marple Miller cascade impactor model 150 an...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2015
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2015.08.051